A CASE OF INSULIN RESISTANCE TREATED WITH CORTICOTROPIN
- 1 May 1956
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 16 (5) , 680-686
- https://doi.org/10.1210/jcem-16-5-680
Abstract
Insulin resistance developed in a case of diabetes. The diabetes could not be regulated by regular insulin up to 600 units daily. Administration of corticotropin permitted reduction of insulin to 100 units daily. The presence of an anti-insulin factor in the patient''s serum could be demonstrated on mice simultaneously with the presence of resistance to insulin. With disappearance of the resistance, the insulin neutralizing factor in the serum also disappeared.Keywords
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