Phase I Study of the Cyclin-Dependent Kinase Inhibitor Flavopiridol in Combination With Paclitaxel in Patients With Advanced Solid Tumors
- 15 April 2002
- journal article
- clinical trial
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 20 (8) , 2157-2170
- https://doi.org/10.1200/jco.2002.08.080
Abstract
PURPOSE: Preclinical studies indicate that the cyclin-dependent kinase inhibitor flavopiridol potentiates the induction of apoptosis by paclitaxel, provided paclitaxel is followed by flavopiridol. ...Keywords
This publication has 17 references indexed in Scilit:
- Phase II Study of the Cyclin-Dependent Kinase Inhibitor Flavopiridol Administered to Patients With Advanced Gastric CarcinomaJournal of Clinical Oncology, 2001
- The Cyclin-Dependent Kinase (CDK) Inhibitor Flavopiridol Inhibits Glycogen PhosphorylaseArchives of Biochemistry and Biophysics, 2001
- Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol.International Journal of Oncology, 2000
- Flavopiridol Inhibits P-TEFb and Blocks HIV-1 ReplicationJournal of Biological Chemistry, 2000
- Flavopiridol, A Novel Cyclin-Dependent Kinase Inhibitor, in Metastatic Renal Cancer: A University of Chicago Phase II Consortium StudyJournal of Clinical Oncology, 2000
- Activity of Taxol in Patients With Squamous Cell Carcinoma and Adenocarcinoma of the EsophagusJNCI Journal of the National Cancer Institute, 1994
- Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275Biochemical and Biophysical Research Communications, 1994
- Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells: Correlation with decreased H1 kinase activityBiochemical Pharmacology, 1993
- Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-8275JNCI Journal of the National Cancer Institute, 1992
- An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from dysoxylum binectariferum : isolation, structure and total synthesisTetrahedron, 1988