Genetic and sex‐linked factors influencing hbs antigen clearance 1. nonimmune clearance in inbred strains of mice
- 1 January 1982
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 9 (2) , 117-123
- https://doi.org/10.1002/jmv.1890090206
Abstract
Differences in the clearance values of polyvinylpyrrolidonc (KPVP) and HBs antigen (KHBs) were seen in several strains of inbred mice. In addition, in all strains studied KHBs was greater in females than in males, while KPVP was not significantly different in the two sexes. In the strain with the lowest KHBs values, the incidence of HBs antibody formation was lower than in the other strains. These data indicate that genetic and sex‐linked factors influence nonimmune clearance of HBs antigen in mice. If similar factors exist in man they may explain some of the variation in clinical manifestation of HBV infection.Keywords
This publication has 12 references indexed in Scilit:
- Theimunopathogenesis of cronic HBV inducedliver diseaseSpringer Seminars in Immunopathology, 1981
- Evidence that hepatitis B surface antigen and H-Y antigen do not cross-reactImmunogenetics, 1979
- Hepatitis B Virus and Sex Ratio of OffspringScience, 1978
- The Regulation of Lymphocyte Functions by the MacrophageImmunological Reviews, 1978
- Enhanced HBsAb production in pathogenesis of fulminant viral hepatitis type B.BMJ, 1976
- Nonspecific Immunoregulation by Macrophages and Their ProductsPublished by Elsevier ,1976
- Relationship between macrophage clearance of PVP and affinity of anti-protein antibody response in inbred mouse strainsNature, 1975
- INADEQUATE ANTIBODY RESPONSE TO HBAg OR SUPPRESSOR T-CELL DEFECT IN DEVELOPMENT OF ACTIVE CHRONIC HEPATITISThe Lancet, 1974
- Antibody to Hepatitis-Associated AntigenPublished by American Medical Association (AMA) ,1972
- Antibody to hepatitis-associated antigen. Frequency and pattern of response as detected by radioimmunoprecipitationPublished by American Medical Association (AMA) ,1972