Increases in transforming growth factor‐β mRNA in hippocampus during response to entorhinal cortex lesions in intact and adrenalectomized rats

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Abstract
Transforming growth factor‐β mRNA was detected with a rat TGF‐β1 coding sequence probe as a 2.5 kb band by RNA blot hybridization of total RNA from the adult male rat hippocampus. Following electrolytic lesions of the entorhinal cortex that cause hippocampal deaffer entation and synaptic remodeling, TGF‐β mRNA increases 5‐fold in ipsflateral hippocampus when compared with intact controls. This increase was independent of prior adrenalectomy or corticosterone‐replacement. These data demonstrate that TGF‐β gene expression increases in response to hippocampal deafferentation.