Brain lesions following combined treatment with methotrexate and craniospinal irradiation
- 1 April 1991
- journal article
- Published by Springer Nature in Journal of Neuro-Oncology
- Vol. 10 (2) , 165-171
- https://doi.org/10.1007/bf00146878
Abstract
Eight patients with meningeal seeding by carcinoma or lymphomas were treated with intravenous (i.v.) and/or intrathecal (i.th.) Methotrexate (MTX). Seven patients received additional craniospinal irradiation and in all seven a fatal encephalopathy developed. On the bases of clinical and morphological findings we identified an acute and a delayed form of encephalopathy and concluded that the concurrent administration of Methotrexate and of craniospinal irradiation increases considerably the risk of brain damage.Keywords
This publication has 18 references indexed in Scilit:
- A method for microscopic studies of cerebral angioarchitecture and vascular- parenchymal relationships, based on the demonstration of ·paravascular’ fluid pathways in the mammalian central nervous systemJournal of Neuroscience Methods, 1985
- Case 6-1985New England Journal of Medicine, 1985
- Acute changes in blood-CSF barrier permselectivity to serum proteins after intrathecal methotrexate and CNS irradiationZeitschrift für Neurologie, 1985
- Intraventricular methotrexate therapy of leptomeningeal metastasis from breast carcinomaNeurology, 1983
- Iatrogenic Damage to the Central Nervous System in Malignant Systemic DiseasePublished by Springer Nature ,1981
- Methotrexate encephalopathyHuman Pathology, 1978
- Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia.BMJ, 1977
- Leukoencephalopathy in childhood leukemiaNeurology, 1977
- Brain damage after intrathecal methotrexate.Journal of Neurology, Neurosurgery & Psychiatry, 1975
- ‘Prophylactic’ Treatment of Meningeal Leukemia in Children by Intrathecal MethotrexateActa Haematologica, 1972