Synthesis and stereochemistry of dilactones related to strigol
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 512-513
- https://doi.org/10.1039/c39740000512
Abstract
A general approach to the synthesis of strigol (1) analogues has been developed which involves the stereospecific coupling of bromobutenolides (3a) and (3b) with the sodium enolate (2) of 3-(hydroxymethylene)dihydrofuran-2(3H)-one to give dilactones (4a) and (4b) one of which showed significant cytotoxicity against Hela cells in preliminary testing to evaluate the potential anticancer activity of strigol analogues.Keywords
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