Proton NMR Spectrometric Analysis of Glibenclamide and Tolazamide and Some of Their Pharmaceutical Preparations
- 1 September 1983
- journal article
- research article
- Published by Taylor & Francis in Spectroscopy Letters
- Vol. 16 (9) , 673-682
- https://doi.org/10.1080/00387018308062379
Abstract
An analytical method is described for the assay of two important oral hypoglycemic agents, namely, glibenclamide (glyburide); and tolazamide; using PMR technique. The method is rapid, accurate, specific and precise. The principle of the method involves comparing the integral of a chosen signal in the PMR spectrum of the drug under investigation with that of the methylene group signal of the internal standard, benzyl benzoate.Keywords
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