CEREBROSPINAL FLUID NUCLEOTIDE METABOLITES FOLLOWING NON‐CONVULSIVE STATUS EPILEPTICU

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Abstract
The authors studied specific and sensitive indicators of neuronal adenosine triphosphate (ATP) depletion-hypoxanthine, xanthine and uridine levels- in the cerebrospinal fluid (CSF) of nine children during non-convulsive status epilepticus. No evidence of ATP depletion was found and CSF pH and creatine kinase levels were similar to those of controls. Hypoxanthine, xanthine and uridine had a tendency to be low, but this was significant ony for xanthine. The authors speculatively link this reduction to a reduction in neural protein synthesis. This might be a mechanism whereby non-convulsive status epilepticus could lead to intellectual deterioration and dementia.