Role of syntaxin in mouse pancreatic beta cells

1 July 1995

journal article
research article
Published by Springer Nature in Diabetologia

Vol. 38 (7) , 860-863
https://doi.org/10.1007/s001250050364

Abstract

The role of syntaxin 1, a protein involved in the docking of synaptic vesicles at presynaptic active zones, has been investigated in pancreatic islet cells. Using two different monoclonal antibodies we have shown that syntaxin 1 is present in the pancreatic islet cell microsomal fraction. Furthermore, functional experiments demonstrate that anti-syntaxin antibodies inhibit Ca²⁺-dependent insulin secretion in permeabilized islet cells. These data indicate that syntaxin 1 is present in the pancreatic beta cell and it is likely to play a functional role in the exocytosis of secretory granules.

Keywords

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Published by Elsevier ,1974