6-keto-prostaglandin E1-stimulated bone resorption in organ culture
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Calcified Tissue International
- Vol. 36 (1) , 380-383
- https://doi.org/10.1007/bf02405349
Abstract
Previous investigations have shown that prostaglandin E2 (PGE2), 13,14-dihydro-PGE2, and prostacyclin (PGI2) are among the most potent prostaglandin stimulators of bone resorption. 6-Ketoprostaglandin F1α (6-keto-F1α; also called 6-oxo-prostaglandin F1α), a metabolite of PGI2 formed by spontaneous hydrolysis, has little bone resorptive or other biological activity. The present study demonstrated that another metabolite of PGI2, 6-keto-prostaglandin E1 (6-keto-PGE1; also called 6-oxo-prostaglandin E1), was active in stimulating bone resorption in fetal rat long bone organ culture. 6-Keto-PGE1 stimulated significant release of previously incorporated45Ca over the concentration range of 10−9 to 10−5 M. The potency of 6-keto-PGE1 was one-twelfth that of PGE2. If 6-keto-PGE1 is formed by bone or adjacent tissues, or reaches bone through the circulation, it could significantly affect bone mineral metabolism.This publication has 42 references indexed in Scilit:
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