A Differential Effect of Prior Heat Treatment on the Thermal Enhancement of Radiation Damage in the Ear of the Mouse

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Abstract
The effect of prior heat treatment on thermal enhancement of radiodermatitis was investigated in the ear of the mouse. Ears were heated by immersion in hot water. A priming treatment of 43.5.degree. C for 30 min (H) was given at various time before a 2nd combined treatment of hyperthermia at 43.5.degree. C (h) given immediately before (hX) or after (Xh) a dose of X-rays (X). The effect of H was measured in the following 2 ways: the heating time hr required to cause a given enhancement of radiodermatitis was estimated by fixing X and varying the duration of h; the thermal enhancement ratio, defined as the dose of X-rays alone divided by the dose of X-rays with heat required to cause a given reaction, was measured by fixing h and varying X. The priming treatment H reduced the skin response to hX. This effect was such that at 24-96 h after H, the heating time hr had to be increased to .apprx. 1.5 times that required without prior hyperthermia. In contrast, the priming treatment had no effect on the response to Xh. [A differential effect of prior heating on the thermal enhancement of radiation damage to normal and tumor cells will complicate the planning of cancer therapy in which combined treatments are fractionated.].

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