A long-term effect of X rays on thermal sensitivity of the mouse ear

Publisher Website
Google Scholar
Abstract
The response of the mouse ear to hyperthermia was investigated after single doses of X-rays. A dose of 15 Gy [grays], which alone caused no visible effect, increased thermal sensitivity at 1-2 wk after irradiation. There was a slight recovery at 4-6 wk, but thermal sensitivity was still increased at 6 mo. When heat treatment was given at 1 wk or 24 wk after X-ray doses ranging from 9-18 Gy, it was found that thermal sensitivity increased as the dose was increased above 10 Gy. Although there are reports which indicate that prior radiotherapy given > 2 mo. earlier does not affect normal tissue response to the mild hyperthermia currently being used to treat patients, more aggressive heat therapy may produce unexpected responses at previously irradiated sites. [The use of hyperthermia to treat superficial tumors is discussed.].

This publication has 8 references indexed in Scilit: