Measurement of cardiac output distribution using microspheres. Some practical and theoretical considerations
- 1 July 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 8 (4) , 570-581
- https://doi.org/10.1093/cvr/8.4.570
Abstract
The distribution of radioactive microspheres (15 μ, 25 μ, and 50 μ diameter) following left atrial injection in the conscious uninjured rabbit and the limitations of sphere size and dose in multiple injection techniques are described. Shunting of spheres through the ears and hind limb increased as sphere size decreased. No shunting of spheres occurred through the liver, gut, kidneys, or lungs. Rheological factors may influence the distribution of 50 μ spheres. The degree of shunting through the systemic circulation was decreased by barbiturate anaesthesia. The incidence of haemodynamic and behavioural side-effects of microspheres increased with sphere size.Keywords
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