Risk of Cataract in Patients Treated With Statins

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Abstract
INHIBITORS OF hydroxymethylglutaryl coenzyme A reductase (statins) are effective drugs to decrease morbidity and mortality in patients with hypercholesterolemia.1-3 Although the overall safety profile of the marketed statins has been shown to be favorable in humans,4 concerns have arisen on the basis of long-term animal studies showing that some statins (eg, simvastatin, fluvastatin) are cataractogenic when administered at excessive doses.5,6