Synthesis of a novel GC-specific covalent-binding DNA affinity-cleavage agent based on pyrrolobenzodiazepines (PBDs)

1 January 1996

journal article
research article
Published by Royal Society of Chemistry (RSC) in Chemical Communications

No. 4,p. 563-565
https://doi.org/10.1039/cc9960000563

Abstract

A novel GC-selective pyrrolobenzodiazepine–EDTA conjugate is synthesized that covalently binds to DNA at 5′-PuGPu sequences leading to site-specific cleavage.

Keywords

PYRROLOBENZODIAZEPINES
SITE SPECIFIC
AGENT BASED
DNA AFFINITY
AFFINITY CLEAVAGE
GC SELECTIVE
GC SPECIFIC
SPECIFIC CLEAVAGE
EDTA CONJUGATE

This publication has 0 references indexed in Scilit: