Ultrasonically enhanced transdermal drug delivery. Experimental approaches to elucidate the mechanism
- 1 January 1994
- journal article
- Published by Taylor & Francis in Journal of Biomaterials Science, Polymer Edition
- Vol. 5 (1-2) , 147-156
- https://doi.org/10.1163/156856294x00716
Abstract
The effect of therapeutic range ultrasound on skin permeability was studied in vitro. Permeating molecule ionization state, pH, ultrasound duration, reversibility of the enhancement phenomenon, and skin structural alterations were evaluated. It was found that ultrasound affects the permeability of both ionized and unionized molecules. No irreversible structural alterations due to the ultrasound exposure were detected in the stratum corneum. Ultrasound enhancing mechanism was discussed.Keywords
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