SYNTHESIS OF ANTIBODIES AND IMMUNOGLOBULINS BEARING RECIPIENT ALLOTYPIC MARKERS AND DONOR IDIOTYPIC SPECIFICITIES IN IRRADIATED RABBITS GRAFTED WITH ALLOGENEIC CELLS FROM HYPER-IMMUNE DONORS

  • 1 January 1979
    • journal article
    • research article
    • Vol. C130  (3) , 397-406
Abstract
Irradiated rabbits were grafted with a mixture of bone marrow, lymph node and spleen cells from donors hyperimmunized against TMV [tobacco mosaic virus]. Recipient and donors were characterized by different a allotypic specificities. Antibodies synthesized in the recipients displayed allotypic markers from the recipients but idiotypic specificities cross-reactive with those of donor antibodies. The differentiation of new host B [bone marrow-derived] cells was influenced by the presence of donor memory cells and the results were interpreted in the light of network concepts.

This publication has 0 references indexed in Scilit: