Regulatory squelching
- 16 May 1994
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 344 (2-3) , 105-108
- https://doi.org/10.1016/0014-5793(94)00320-3
Abstract
An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle‐dependent and differentiation‐specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be more important than hitherto appreciated.Keywords
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