Theory of Multicapillary Columns for HPLC

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Abstract
A study was undertaken of the theoretical aspects of bundling together either solid or hollow fiber capillaries in order to overcome the severe volumetric problems of single capillary HPLC. These calculations predict that multicapillary columns can exceed the performances of packed beds over a wide range of efficiencies if variations in linear velocity between capillaries can be maintained at about 1% or less. The porosities, phase ratios, and other geometric properties of both solid and hollow fiber multicapillary columns also were calculated. A first-trial column was constructed from several thousand solid fused-silica fibers of 35-μm diameter. While the chromatographic performance of this first column was disappointing, the use of technologies from the emerging fiber optics industry may yield columns with suitably high precisions.

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