THE EFFECT OF STILBAMIDINE AND PROPAMIDINE ON THE OXIDATIVE METABOLISM OF BLASTOMYCES DERMATITIDIS

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Abstract
Both drugs inhibited respiration of the organism in the presence of glucose, Na pyruvate, Na lactate, Na oxalacetate, Na succinate, Na acetate, DL-alanine, DL-serine, phenylalanine, and methionine. The endogenous respiration of the organism was also inhibited. A correlation was observed between concns. of the drugs which inhibited growth and those which inhibited O2 uptake''. Stilbamidine was more effective than propamidine in inhibiting growth and respiration of the organism.