Signalling through the lipid products of phosphoinositide-3-OH kinase
- 12 June 1997
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 387 (6634) , 673-676
- https://doi.org/10.1038/42648
Abstract
When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear.Keywords
This publication has 47 references indexed in Scilit:
- PI3K: Downstream AKTion Blocks ApoptosisCell, 1997
- Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphateScience, 1997
- Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by PhosphorylationJournal of Biological Chemistry, 1996
- A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegansNature, 1996
- Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteinsCell, 1995
- Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transductionNature, 1995
- The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseCell, 1995
- Phosphatidylinositol-3-OH kinase direct target of RasNature, 1994
- An inositol tetrakisphosphate-containing phospholipid in activated neutrophilsNature, 1988
- Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphateNature, 1988