Norepinephrine-induced eating: Its hypothalamic locus and an alternate interpretation of action.

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Abstract
Implanted intracranial cannulas in 91 male holtzman rats to determine the neuroanatomical site yielding the greatest eating in response to an injection of norepinephrine bitartrate (ne). The optimal site was found to be the anterior medial hypothalamus, just at the midpoint of the paraventricular nucleus. 10 ss were used to evaluate the hypothesis that ne induces eating by its effect upon the metabolic activity of cells, rather than through its action as a cellular transmitter. The prediction tested was that altering cellular metabolic rates by inducing systemic hypoglycemia should potentiate ne-induced eating. Either 4 units of insulin or .1 cc of saline were injected subcutaneously 1/2 hr. Before the intracranial injection of ne. As predicted, insulin differentially enhanced the magnitude of the ne eating effect. Further implications of the metabolic interpretation of ne action are discussed. (22 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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