Antiprolactin and Experimentally-Induced Hepatic Metastases.

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Abstract
Summary Neither prolactin nor anti-prolactin affected the incidence or size of hepatic metastases in intact rats following the intraportal injection of Walker tumor cells. These failures were unrelated to the mammary changes induced by this hormone or its antibody. On the other hand, antiprolactin moderately inhibited the tumor growth-promoting effect of prolactin in hypophys-ectomized rats. This suggests that one factor concerned with the failure noted in intact members may be related to the quantity of antibody required to inhibit tumor growth when endogenous prolactin secretion is maintained.

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