IN VIVO AUGMENTATION OF THYROTROPIC HORMONE AND PARTIAL REACTIVATION OF IODINATED (INACTIVE) THYROTROPIC HORMONE EXTRACT BY GOITROGENS1

Publisher Website
Google Scholar
Abstract
IN PREVIOUS studies we have shown that a pituitary extract was rendered incapable of exerting a thyroid stimulating action after in vitro treatment with elementary iodine. The inactivation was readily reversed by reducing compounds both goitrogenic and non-goitrogenic. Furthermore, it was found that the thyrotropic potency of the untreated pituitary extract was enhanced by exposure in vitro to small amounts of goitrogens (Albert and Rawson, 1946; Albert, Rawson, Merrill, Lennon and Riddell, 1946, 1947a, b). From these reactions several interesting possibilities concerning the interaction in vivo of thyroid stimulating hormone and the goitrogens arise. It is our purpose to present experiments indicating that a partial reactivation of iodinated (inaotivated) thyrotropic extract and an enhancement of untreated (active) thyrotropic extract can be induced in vivo by goitrogenic compounds.
Keywords