The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in In Vitro Cellular & Developmental Biology - Plant
- Vol. 21 (1) , 26-31
- https://doi.org/10.1007/bf02620910
Abstract
Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [3H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.Keywords
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