Reliability and Usefulness of Random Fecal α1-Antitrypsin Concentration

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Abstract
The reliability of random fecal .alpha.1-antitrypsin (FA-1-AT) concentration was evaluated by comparing FA-1-AT values on random specimens and on concomitant 24-72 h fecal collections. To simplify the method, Fa-1-AT data derived from lyophilized fecal samples were compared with those obtained from 37.degree. C heat-dried fecal samples. Random FA-1-AT concentration was assayed in 80 children with various gastrointestinal illnesses and 36 healthy age-matched controls. There was a close relationship between FA-1-AT values obtained from random samples and 1-day or 3-day collections. There was also a significant relationship between Fa-1-AT values derived from the 2 different ways of drying the stools. Mean FA-1-AT values were statistically different when compared to the controls in the following groups of disorders; untreated and after-gluten-challenge celiac disease, post-enteritis syndrome and cow''s milk intolerance. The possible meanings of the abnormal FA-1-AT concentration in the various disorders are discussed. FA-1-AT is a simple and reliable test for enteric protein loss. The simplification of the method proposed by us should reduce the cost of the test and moreover make it feasible in all laboratories.