Nitrogen Balances of Adults Given Leucine and Valine

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Abstract
Adult human subjects were fed increasing quantities of leucine or valine in conjunction with 1.5 times the basic mixture of other amino acids previously developed in this laboratory. White wheat flour and crystalline amino acids were administered. Total daily nitrogen intake was 6.00 g. Mean nitrogen balances were 0.22, 0.36, 0.40, 0.40, and 0.22 g, respectively, when 1.30, 1.95, 2.90, 4.40, and 6.60 g of leucine were administered, and they were 0.20, 0.34, 0.09, and 0.14 g when 1.50, 3.00, 4.50, and 6.00 g of valine were provided. A wide zone of tolerance evidently existed for leucine and valine when adequate amounts of other essential amino acids were consumed.

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