EFFECT OF CHLORPROMAZINE ON STRESS INDUCED ADRENAL ASCORBIC ACID DEPLETION1

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Abstract
Chlorpromazine injected subcutaneously did not cause adrenal ascorbic acid depletion in either anesthetized or unanesthetized rats, when compared with saline as a control. Adrenal ascorbic acid depletion produced by sham adrenalectomy, unilateral adrenalectomy, or epinephrine was effectively inhibited by prior administration of chlorpromazine; vasopressin depletion was unaffected by chlorpromazine. Adrenal ascorbic acid depletion produced by exogenous corticotropin in hypophysectomized rats was also unaffected by chlorpromazine. The inhibitory effects of chlorpromazine on stress induced adrenal ascorbic acid depletion are discussed with reference to other inhibitory agents (Dibenzyline, adrenal cortex extract, morphine). An attempt was made to explain some of the discrepancies among various reports relating to this problem.