Role of Motility and Flagellin Glycosylation in the Pathogenesis of Pseudomonas aeruginosa Burn Wound Infections
Open Access
- 1 July 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (7) , 4395-4398
- https://doi.org/10.1128/iai.73.7.4395-4398.2005
Abstract
In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.Keywords
This publication has 52 references indexed in Scilit:
- Glycosylation of b-Type Flagellin of Pseudomonas aeruginosa : Structural and Genetic BasisJournal of Bacteriology, 2006
- Flagella and Chemotaxis Are Required for Efficient Induction ofSalmonella entericaSerovar Typhimurium Colitis in Streptomycin-Pretreated MiceInfection and Immunity, 2004
- Structural and Genetic Characterization of Glycosylation of Type a Flagellin in Pseudomonas aeruginosaJournal of Bacteriology, 2004
- Sequence Polymorphism in the Glycosylation Island and Flagellins of Pseudomonas aeruginosaJournal of Bacteriology, 2004
- Flagellin Glycosylation Island in Pseudomonas syringae pv. glycinea and Its Role in Host SpecificityJournal of Bacteriology, 2003
- Campylobacter Protein Glycosylation Affects Host Cell InteractionsInfection and Immunity, 2002
- Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence ofSalmonella entericaSerovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf EnterocolitisInfection and Immunity, 2001
- FlhA, a Component of the Flagellum Assembly Apparatus of Pseudomonas aeruginosa , Plays a Role in Internalization by Corneal Epithelial CellsInfection and Immunity, 2001
- A murine model with aspects of clinical relevance for the study of antibiotic-induced endotoxin release in septic hostsInnate Immunity, 1996
- The hrp gene locus of Pseudomonas solanacearum, which controls the production of a type III secretion system, encodes eight proteins related to components of the bacterial flagellar biogenesis complexMolecular Microbiology, 1995