Citrullination, a possible functional link between susceptibility genes and rheumatoid arthritis
Open Access
- 1 January 2004
- journal article
- Published by Springer Nature in Arthritis Research & Therapy
- Vol. 6 (1) , 1-5
- https://doi.org/10.1186/ar1027
Abstract
Antibodies directed to citrullinated proteins (anti-cyclic citrullinated peptide) are highly specific for rheumatoid arthritis (RA). Recent data suggest that the antibodies may be involved in the disease process of RA and that several RA-associated genetic factors might be functionally linked to RA via modulation of the production of anti-cyclic citrullinated peptide antibodies or citrullinated antigens.Keywords
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