INDUCTION OF INTESTINAL METAPLASIA AND CARCINOMA IN THE GLANDULAR STOMACH OF RATS BY N-ALKYL-N'-NITRO-N-NITROSOGUANIDINES

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 70  (2) , 181-185
Abstract
Induction of intestinal metaplasia and carcinoma of the stomach in Wistar rats by 4 homologs of N-alkyl-N''-nitro-N-nitrosoguanidine (N-alkyl-NNG) was investigated. N-Propyl-, N-butyl-, N-isobutyl and N-pentyl-NNG were administered to rats as 0.34 mM solutions in the drinking water for 12 mo. and the rats were killed about 6 mo. later. Intestinal metaplasia was found in the glandular stomach of 100%, 50%, 44% and 17% of the rats treated with N-propyl-, N-butyl-, N-isobutyl-, and N-pentyl-NNG, respectively. Adenocarcinoma of the glandular stomach was found in 29% of the rats treated with N-propyl-NNG, but not in those treated with other N-alkyl-NNG. In the control group, 11% of the rats had intestinal metaplasia but none had tumors.