PURPURA HAEMORRHAGICA IN CONGENITAL SYPHILIS FOLLOWING ARSPHENAMINE

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Abstract
Studies of the toxic effects of the arsphenamine derivatives have received a prominent place in the literature as the extent of the usage of these drugs has increased in the treatment of syphilis. To the list of untoward reactions caused by them have been added the blood dyscrasias. That a selective injury of one of the elements of the hematopoietic system may be caused by the arsphenamine preparations is shown by the reports of (1) cases of granulocytopenia, in which there results a suppression of the granulocytic series, or (2) of cases of purpura haemorrhagica in which a thrombocytopenia is the conspicuous feature, or (3) of cases of aplastic anemia in which there is a generalized depression of all types of blood formation. The severity of the blood disorder is variable; in some there is complete recovery with restoration to a normal blood picture; in others, the outcome is fatal.

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