PLASMA RETENTION, URINARY EXCRETION AND EFFECT UPON CIRCULATING TOTAL RED CELL VOLUME OF INTRAVENOUS GELATIN IN DOGS WITH DIMINISHED PLASMA VOLUME

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Abstract
A decrease in plasma volume was produced in anesthetized dogs by occlusion of the circulation to the hind limbs by means of tourniquets. Infused gelatin solns. were found to leave the plasma and to be excreted in the urine at approx. the same rate as in the normal unanesthetized dog. Within 6 hrs. 56-63% and within 24 hrs. 80-90% of the gelatin had disappeared from the plasma. Within 24 hrs. 30-37% of the gelatin disappearing from the plasma was recovered in the urine. An inverse relationship was found between the plasma volume and the calculated red cell vol., so that the total blood vol. remained practically constant. No decrease in circulating total red cell vol. below the control value was found, as was the case with normal unanesthetized dogs.

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