Hypertrophic Cardiomyopathy — Beyond the Sarcomere
- 30 April 1998
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 338 (18) , 1303-1304
- https://doi.org/10.1056/nejm199804303381810
Abstract
Remodeling of the left ventricle by the process of hypertrophy is usually a response to increased afterload. This adaptive reaction maintains cardiac output. The most common pattern of hypertrophy is concentric remodeling due to systemic hypertension, in which there is replication of sarcomeres in parallel. Hypertrophy also results from genetic mutations involving the contractile apparatus, as in hypertrophic cardiomyopathy, which is unrelated to changes in afterload.Echocardiography has made it possible to quantify hypertrophy and to describe the effects of hypertrophic cardiomyopathy on left ventricular architecture and function. These patterns have proved invaluable in identifying phenotypic expression in family pedigrees. . . .Keywords
This publication has 14 references indexed in Scilit:
- Mutations in the Gene for Cardiac Myosin-Binding Protein C and Late-Onset Familial Hypertrophic CardiomyopathyNew England Journal of Medicine, 1998
- Transcription and the broken heartNature, 1998
- The phenotype/genotype relation and the current status of genetic screening in hypertrophic cardiomyopathy, Marfan syndrome, and the long QT syndrome.Heart, 1997
- Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathyNature Genetics, 1997
- Expression and functional assessment of a truncated cardiac troponin T that causes hypertrophic cardiomyopathy. Evidence for a dominant negative action.Journal of Clinical Investigation, 1996
- A Mouse Model of Familial Hypertrophic CardiomyopathyScience, 1996
- Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic MiceJournal of Biological Chemistry, 1995
- Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy.Journal of Clinical Investigation, 1995
- α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomereCell, 1994
- Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart StudyNew England Journal of Medicine, 1990