Adrenal Function and the Effect of a High-Fat Diet on C57BL/6J and C57BL/6J-ob/ob Mice

Publisher Website
Google Scholar
Abstract
In C57BL/6J mice and the ob/+ and ob/ob mutants total plasma corticosterone levels were found to be statistically different. In C57BL/6J mice the level was 1.9 ± 0.2 µg/100 ml plasma, in ob/+ mice 8.6 ± 1.6 µg/100 ml and in ob/ob mice 13.7 ± 1.5 µg/100 ml. The percentage of protein-bound corticosterone as well as the free endogenous corticosterone levels were also different. Feeding a high-fat diet to young C57BL/6J and C57BL/6J-ob/ob mice for a period of 4 weeks had no effect upon blood glucose, plasma insulin and plasma corticosterone levels. The significantly higher increase in body weight of the high-fat diet groups of both lines of mice was mainly due to fat cell hypertrophy.

This publication has 0 references indexed in Scilit: