Selective isomerization of 1,2-epoxyalkanes to aldehydes with lithium dialkylamides
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 2103-2104
- https://doi.org/10.1039/c39940002103
Abstract
Reaction of a variety of 1,2-epoxyalkanes with 2.5 equiv. of bulky metal amide—lithium 2,2,6,6-tetramethylpiperidide—affords the corresponding aldehydes exclusively in high yields; this is the first example of base-promoted isomerization of monosubstituted epoxides to aldehydes.Keywords
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