Depression of Cellular Immunity in Pregnancy due to a Serum Factor
- 8 September 1973
- Vol. 3 (5879) , 513-514
- https://doi.org/10.1136/bmj.3.5879.513
Abstract
Lymphocytes from pregnant women and non-pregnant individuals were cultured under the stimulus of phytohaemagglutinin in the presence of their own and heterologous (allogeneic) sera. The results indicate that heterologous sera have an inhibitory effect on the lymphocyte transformation rate and suggest that the inhibitory property is more powerful in pregnant and fetal sera. Conversely, the addition of heterologous non-pregnant sera to cultures of pregnant lymphocytes increases their transformation rate. These findings suggest that there is a serum inhibitor in pregnancy and this finding may be relevant to the survival of the fetal allograft.Keywords
This publication has 13 references indexed in Scilit:
- Lymphocyte reactivity in pregnancy.BMJ, 1972
- MEASLES, MULTIPLE SCLEROSIS, AND ENCEPHALITOGENIC FACTORThe Lancet, 1972
- DEPRESSED MATERNAL LYMPHOCYTE RESPONSE TO PHYTOHÆMAGGLUTININ IN PREGNANCYThe Lancet, 1972
- DEPRESSED LYMPHOCYTE RESPONSE TO P.H.A. IN WOMEN TAKING ORAL CONTRACEPTIVESThe Lancet, 1972
- DEPRESSED MATERNAL LYMPHOCYTE RESPONSE TO PHYTOHÆMAGGLUTININ IN HUMAN PREGNANCYThe Lancet, 1972
- SERUM INHIBITORS OF LYMPHOCYTE RESPONSESThe Lancet, 1971
- REDUCED LYMPHOCYTE TRANSFORMATION IN BREAST CANCERThe Lancet, 1971
- IMMUNOLOGICAL OBSERVATIONS IN CHRONIC MUCOCUTANEOUS CANDIDIASISThe Lancet, 1969
- [Lymphocytic reactive capacity in the mother after childbirth and in the newborn infant].1969
- Simple Test for Ingested Iron in Hospital and Domiciliary PracticeBMJ, 1966