Immunoglobulin M Heavy Chain Disease: Intracellular Origin of the Mu Chain Fragment
- 21 August 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3947) , 770-773
- https://doi.org/10.1126/science.169.3947.770
Abstract
Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.Keywords
This publication has 11 references indexed in Scilit:
- Biosynthetic And structural studies of a heavy chain disease proteinJournal of Clinical Investigation, 1969
- Immunoglobulin biosynthesis: III. Blocks in defective synthesisJournal of Molecular Biology, 1968
- Alpha-Chain Disease: A New Immunoglobulin AbnormalityScience, 1968
- The polypeptides of adenovirusVirology, 1968
- Time course of labeling of light and heavy chains of immunoglobulin G and the turnover of the free light-chain intermediatesArchives of Biochemistry and Biophysics, 1968
- Two-Chain Immunoglobulin A Molecules: Abnormal or Normal Intermediates in SynthesisScience, 1968
- Preparation of mammalian polyribosomes with the detergent Nonidet P-40Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967
- Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gelsBiochemical and Biophysical Research Communications, 1967
- The Synthesis, Assembly, and Secretion of Gamma Globulin Polypeptide Chains by Cells of a Mouse Plasma-Cell TumorCold Spring Harbor Symposia on Quantitative Biology, 1967
- Heavy chain disease—A new disorder of serum γ-globulinsThe American Journal of Medicine, 1964