Linkage and recombination between fragile X-linked mental retardation and the factor IX gene
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 69 (1) , 44-46
- https://doi.org/10.1007/bf00295528
Abstract
Linkage analysis on a family with fragile X-linked mental retardation was performed using a Taq 1 restriction fragment length polymorphism detected by a cloned human coagulation factor IX cDNA. Two affected brothers in this sibship were found to have different factor IX RFLP alleles, indicating a recombinational event occurred between the two genes. Our data therefore indicate that the gene responsible for fragile X-linked mental retardation is not as tightly linked to the factor IX gene as the previously published data may suggest.This publication has 16 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Isolation and characterization of human factor IX cDNA: Identification of Taq I polymorphism and regional assignmentSomatic Cell and Molecular Genetics, 1984
- The marker (X) syndrome: a cytogenetic and genetic analysisAnnals of Human Genetics, 1984
- Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).Proceedings of the National Academy of Sciences, 1984
- Close linkage of fragile X-mental retardation syndrome to haemophilia B and transmission through a normal maleNature, 1983
- Marker (X)-Linked Mental RetardationPublished by Springer Nature ,1983
- Isolation of a human anti-haemophilic factor IX cDNA clone using a unique 52-base synthetic oligonucleotide probe deduced from the amino acid sequence of bovine factor IXNucleic Acids Research, 1983
- Isolation and characterization of a cDNA coding for human factor IX.Proceedings of the National Academy of Sciences, 1982
- Molecular cloning of the gene for human anti-haemophilic factor IXNature, 1982
- X‐linked mental retardation: A study of 7 familiesAmerican Journal of Medical Genetics, 1980