Accumulation of Prostacyclin in Rat Brain during Haemorrhagic Hypotension—Possible Role of PGI2in Autoregulation
- 1 March 1984
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 4 (1) , 107-109
- https://doi.org/10.1038/jcbfm.1984.14
Abstract
The effect of haemorrhagic hypotension on the levels of prostaglandin E2(PGE2), thromboxane B2(TXB2), and 6-keto prostaglandin F1α(6-keto-PGF1α) in cortical tissue of rats was studied. Lightly anesthetized rats were subjected to steady-state hypotension for 15 min, with a mean arterial blood pressure of 80, 60, and 40 mm Hg, and compared to a control group of normotensive rats. No significant change was found in the levels of PGE2and TXB2. The level of 6-keto-PGF1αincreased from 7.8 ± 0.9 to 14.1 ± 1.9 pg/mg protein (p < 0.02) at 80 mm Hg. Our findings suggest that prostacyclin, which is a potent vasodilator, might play a role in setting the lower limit of the autoregulation range.Keywords
This publication has 16 references indexed in Scilit:
- The effect of incomplete cerebral ischemia on prostaglandin levels in rat brain.Stroke, 1982
- Role of Prostaglandins and Arachidonic Acid Derivatives in the Coupling of Cerebral Blood Flow to Cerebral MetabolismJournal of Cerebral Blood Flow & Metabolism, 1981
- Local Cerebral Blood Flow Values as Estimated with Diffusible Tracers: Validity of Assumptions in Normal and Ischemic TissueJournal of Cerebral Blood Flow & Metabolism, 1981
- The effect of indomethacin on cerebral blood flow and oxygen consumption in the rat at normal and increased carbon dioxide tensionsActa Physiologica Scandinavica, 1981
- Prostaglandin I2 and indomethacin prevent impairment of post-ischemic brain reperfusion in the dog.Stroke, 1979
- The effect of indomethacin on the blood flow—metabolism couple in the brain under normal, hypercapnic and hypoxic conditionsActa Physiologica Scandinavica, 1979
- Influence of several plasma fractions on post-ischemic microvascular reperfusion in the central nervous system.Stroke, 1978
- Cerebral blood flow autoregulation in the rat.Stroke, 1978
- HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATIONThe Lancet, 1977
- Changing Attitudes towards Science among AdolescentsNature, 1973