Interactions of spironolactone with (+)‐[3H]‐isradipine and (−)‐[3H]‐desmethoxyverapamil binding sites in vascular smooth muscle

Open Access
Publisher Website
Google Scholar
Abstract
Spironolactone partially inhibited the specific binding of (+)‐[3H]‐isradipine and (−)‐[3H]‐desmethoxyverapamil to vascular smooth muscle membranes. It is suggested that spironolactone interacts at a binding site of the calcium channel complex and allosterically modulates ligand binding at receptor sites in the channel.