The hydroxylation and dealkylation of some naphthyl alkyl ethers by rat liver microsomes
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 11 (3) , 179-188
- https://doi.org/10.3109/00498258109045290
Abstract
1. The dealkylation and side-chain hydroxylation of 1 -(4-acetylnaphthyl) ethers by rat liver microsomes is described. The proportions of compounds metabolized by both routes are determined and shown to vary according to the length of the alkyl side-chain. 2. Metabolites formed by side-chain hydroxylation are identified by g.l.c.-mass spectrometry and by comparison with authentic materials.This publication has 16 references indexed in Scilit:
- The dealkylation of some p-nitrophenylalkylethers and their α-deuterated analogues by rat liver microsomesBiochemical Pharmacology, 1975
- Migration of deuterium during hydroxylation of aromatic substrates by liver microsomes: I. Influence of ring substituentsArchives of Biochemistry and Biophysics, 1968
- The metabolism of some 4-acetyl-1-naphthyl ethers in the rat and their effect upon liver microsomal oxidationBiochemical Pharmacology, 1968
- Metabolism of Drugs. LI. The Metabolic Fate of Alkylaryl Ethers in RabbitsCHEMICAL & PHARMACEUTICAL BULLETIN, 1966
- The Anticonvulsant Activities of Some Substituted AcetonaphthonesJournal of Medicinal Chemistry, 1964
- Demethylation Studies. IV. The in vitro and in vivo Cleavage of Alkyl- and Arylalkyl-p-nitrophenyl EthersJournal of Medicinal Chemistry, 1963
- Domethylation Studies--I., The Effect of Chemical Structure and Lipis SolubilityJournal of Medicinal Chemistry, 1961
- Protein Determination of Large Numbers of SamplesAnalytical Chemistry, 1959
- A Synthesis of 1,3-Butylene OxideJournal of the American Chemical Society, 1953
- On PhenyletheraseExperimental Biology and Medicine, 1947