Treatment of Experimental Frostbite With Pentoxifylline and Aloe Vera Cream

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Abstract
Objective: To compare the therapeutic effects of systemic pentoxifylline and topical aloe vera cream in the treatment of frostbite. Design: The frostbitten ears of 10 New Zealand white rabbits were assigned to one of four treatment groups: untreated controls, those treated with aloe vera cream, those treated with pentoxifylline, and those treated with aloe vera cream and pentoxifylline. Main Outcome Measures: Tissue survival was calculated as the percent of total frostbite area that remained after 2 weeks. Results: The control group had a 6% tissue survival. Tissue survival was notably improved with pentoxifylline (20%), better with aloe vera cream (24%), and the best with the combination therapy (30%). Conclusion: Pentoxifylline is as effective as aloe vera cream in improving tissue survival after frostbite injury. (Arch Otolaryngol Head Neck Surg. 1995;121:678-680)

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