The effect of treatment with recombinant γ-interferon on adjuvant-induced arthritis in rats

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Abstract
We have investigated the effects of recombinant rat γ-interferon (rIFNγ) on adjuvant-induced arthritis (AA). Lewis rats, inoculated in the left hind-paw with adjuvant (day 0), were given 105 U/rat of rIFNγ daily (days 0 to 20), subcutaneously and intramuscularly on alternate days. rIFNγ suppressed the secondary phase of swelling of both hind-paw on and after day 18 without influencing the earlier phases, both primary and secondary, of swelling. rIFNγ also reduced the hind-paw bone lesions, the degree of splenomegaly, and the increase in erythrocyte sedimentation rate and plasma fibrinogen. These results indicate a new aspect of the regulatory role of IFNγ in chronic inflammation.