Influenza Virus Growth and Antibody Response in Amantadine-Treated Mice

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Abstract
Summary: Amantadine (1-adamantanamine), a symmetrical primary amine, reduces the mortality rate and increases the survival time of mice infected with influenza A viruses. Virus production, although not completely prevented, is considerably diminished in treated mice. Treated survivors are generally resistant to challenge with homologous virus when the primary infecting virus inoculum is high. With a low primary virus dose a small percentage of treated mice escape an immunizing infection.