Cytogenetic study on eleven cutaneous neoplasms and two pre‐tumoral lesions from xeroderma pigmentosum patients
- 15 July 1989
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 44 (1) , 79-83
- https://doi.org/10.1002/ijc.2910440115
Abstract
Eleven independent tumors (5 basal-cell carcinomas, 5 squamous-cell carcinomas and 1 malignant melanoma), 2 pre-tumoral lesions and one common nevus, developing in the skin of 10 unrelated XP patients were cytogenetically analyzed. No specific chromosomal changes were observed. Two features were relevant, however: emergence of several independent clones and over-involvement of telomeric and cen-tromeric regions in the formation of chromosomal rearrangements, jumping translocations were observed in 2 squamous-cell carcinomas involving telomeric and centromeric regions.This publication has 16 references indexed in Scilit:
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