Fatty Acyl-CoA Oxidase in Rat Kidney and Liver after Application of Thyroxine
- 1 July 1986
- journal article
- research article
- Published by S. Karger AG in Enzyme
- Vol. 35 (1) , 27-33
- https://doi.org/10.1159/000469315
Abstract
Male rats were fed a standard diet containing 2.5 mg% L-thyroxine. After 10 and 20 days, in postnuclear fractions of the kidney the specific activity of fatty acyl-CoA oxidase, the enzyme responsible for the rate-limiting first step of peroxisomal fatty acid ß-oxidation, was increased by 100 and 160%, respectively. A similar effect was found in the liver. It is suggested that thyroxine essentially affects only this step of the fatty acid ß-oxidation sequence. Presumably the elevation of fatty acyl-CoA oxidase is one reason for the beneficial action of thyroid hormones in toxic lesions of the kidney.Keywords
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