Acid-Base Equilibria in Aqueous Solutions of Tetracycline Hydrochloride.
- 1 January 1978
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 32b (2) , 131-136
- https://doi.org/10.3891/acta.chem.scand.32b-0131
Abstract
A UV spectral examination of tetracycline hydrochloride aqueous solution indicated the existence of monoprotonated, neutral, anionic, dianionic and trianionic species across the pH 1-14 range. These findings were supported by molecular orbital, polarographic and biological absorption studies and polarography was further used to study the nature of the complex formed between tetracycline, Ca ions and barbitone.Keywords
This publication has 2 references indexed in Scilit:
- Metal Complexation of the Tetracycline HydrochloridesJournal of Medicinal Chemistry, 1963
- ABSORPTION AND EXCRETION STUDIES ON TETRACYCLINE1959