Conformational Transitions between Enantiomeric 310‐Helices
- 1 November 1987
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 26 (11) , 1150-1152
- https://doi.org/10.1002/anie.198711501
Abstract
The 310‐helix enantiotopermerization of the decapeptide Z‐(Aib)10‐OtBu occurs at 1200 interconversions per second at room temperature. This finding, obtained by 13C‐DNMR measurements, was derived from the coalescence temperature of 265 K for this 3−3‐helix interconversion, observed here for the first time. The corresponding free energy of activation is only 46 kJ mol −1. Aib is the achiral α‐aminoisobutyric acid building block, which is important in drug design.Keywords
This publication has 28 references indexed in Scilit:
- Depth-dependent fluorescent quenching of a tryptophan residue located at defined positions on a rigid 21-peptide helix in liposomesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1987
- Voltage-dependent channel formation by rods of helical polypeptidesThe Journal of Membrane Biology, 1986
- Crystal structure of Z-Aib-Aib-Aib-Ala-Ala-Aib-OtBu, a hexapeptide fragment of trichotoxinBiochemical and Biophysical Research Communications, 1986
- Structural studies of poly(α‐aminoisobutyric acid)Biopolymers, 1986
- Darstellung „chiraler” α-AminoisobuttersäureEuropean Journal of Organic Chemistry, 1985
- Conformation of Boc‐L‐Ala‐Aib‐L‐Ala‐OMe in the Crystal and in SolutionEuropean Journal of Organic Chemistry, 1984
- Peptide Structures of the Alamethicin Sequence: The C‐Terminal α/310 Helical Nonapeptide and Two Pentapeptides with Opposite 310 HelicityAngewandte Chemie International Edition in English, 1984
- Peptidstrukturen der Alamethicin‐Sequenz: Das C‐terminale α/10‐HelicitätAngewandte Chemie, 1984
- Paracelsin, a peptide antibiotic containing α-aminoisobutyric acid, isolated fromTrichoderma ressei Simmons Part ACellular and Molecular Life Sciences, 1983
- Die kinetische und mechanistische Auswertung von NMR-Spektren. Neue analytische Methoden (18)Angewandte Chemie, 1980