Pantothenic Acid Derivatives and Growth of Acetobacter suboxydans

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Abstract
A. suboxydans, which previously was shown to respond to bound forms of pantothenic acid, was examined for its response to various derivatives of the vit. The order of effectiveness observed is roughly: coenzyme A = pantetheine - gamma-phosphate > pantetheine = pantothenylcysteine (approx.)> pantothenic acid = pantoic acid > pantetheine diphosphate > pantothenic acid - alpha- or gamma-phosphate (the last 2 were virtually inactive). Coenzyme A and pantetheine gamma-phosphate are about 10 to 20 times as active as the free vit. for this organism. The above descr. activities of coenzyme A, pantothenyl cysteine, pantetheine, and its gamma-phosphate depend upon the maintenance of these compounds in the reduced form. This may be accomplished by heating the compounds with cysteine or casein hydrolysate, or to a smaller extent with inorganic salts. The superior growth-promoting effects noted with these derivatives indicate that the A. suboxydans stimulatory factor of Novelli is of multiple nature. However, it evidently does not include pantothenic acid phosphates.